Raltegravir (Isentress) may lead to a temporary worsening of pre-existing depression, according to a number of case reports published in the September 12th edition of AIDS. The reports involved four middle-aged treatment-experienced men, all of whom experienced a deterioration in their mental health shortly after starting treatment with raltegravir. All the patients were taking treatment for their depressive illnesses at the time therapy with raltegravir was started, and the investigators speculate that an as yet unknown interaction between raltegravir and psychotropic medication may be the reason for the temporary worsening of the mental health problems observed in these individuals.
http://www.aidsmap.org/en/news/FDC57274-63B8-4BAF-ABC2-09CC5C9ABA19.asp